Cardiovascular Disorders

High exposure levels to Arsenic have been correlated with cardiovascular birth defects in newborn babies.  This particular project examines the effect of in utero (still in the womb) Arsenic exposures in rodents and their cardiovascular development.

  • Pregnant mice were exposed to 10ppb-100ppb concentrations of arsenite (AsO3-3). 
  • The degree of cardiovascular function is dose-dependent, meaning that the higher the dose the more dangerous the birth defect.
  • It was shown that when the embryos were exposed to 50 ppb of Arsenic, they had underdeveloped small arteries and when they were exposed to 50 ppb of Arsenic, they had changes in heart valve structure and had also developed hypertension.
  • High levels also produced changes in the embryo’s heart myocardium, which is a contracting layer of muscle surrounding the heart.

Key Research Highlights