Arsenic Exposure and Gene Mehanism

Relevance to SWEHSC: 

Identified a mechanism by which arsenic exposure induces unique changes in gene expression using bioinformatics resources in the IHSFC and Genomics FC. This is being developed into a biomarker for arsenic-mediated cancers. Translation of the mechanistic basis of arsenic-mediated transcriptional reprogramming allows for the addressing of arsenic-specific mechanism. It leads to development of a strategy to circumvent arsenic-induced cellular changes. An arsenic-specific mechanism allows for the development of a strategy to circumvent arsenic-induced cellular changes. Somatic gene mutation studies could provide biomarkers to differentiate cancers seen in arsenic-exposed populations from those arising from other lung carcinogens. 

Cluster of Efforts: 

Investigator(s):

  • Aikseng Ooi, PhD.
Milestones: 
  • Identified a mechanism by which arsenic exposure induces unique changes in gene expression using bioinformatics resources that is being developed into a biomarker for arsenic-mediated cancers. 
  • Arsenic-specific mechanism allows for the development of a strategy to circumvent arsenic-induced cellular changes. 
  • Ongoing somatic gene mutation studies could provide biomarkers to differentiate cancers seen in arsenic exposed populations from those arising from other lung carcinogens. 
People Terms: 
SWEHSC Terms: